Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis.
Identifieur interne : 000D54 ( Main/Exploration ); précédent : 000D53; suivant : 000D55Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis.
Auteurs : Philipp Schuetz [Suisse] ; Yannick Wirz [Suisse] ; Ramon Sager [Suisse] ; Mirjam Christ-Crain [Suisse] ; Daiana Stolz [Suisse] ; Michael Tamm [Suisse] ; Lila Bouadma [France] ; Charles E. Luyt [France] ; Michel Wolff [France] ; Jean Chastre [France] ; Florence Tubach [France] ; Kristina B. Kristoffersen [Danemark] ; Olaf Burkhardt [Allemagne] ; Tobias Welte [Allemagne] ; Stefan Schroeder [Allemagne] ; Vandack Nobre [Brésil] ; Long Wei [République populaire de Chine] ; Heiner C. Bucher [Suisse] ; Djillali Annane [France] ; Konrad Reinhart [Allemagne] ; Ann R. Falsey [États-Unis] ; Angela Branche [États-Unis] ; Pierre Damas [Belgique] ; Maarten Nijsten [Pays-Bas] ; Dylan W. De Lange [Pays-Bas] ; Rodrigo O. Deliberato [Brésil] ; Carolina F. Oliveira [Brésil] ; Vera Maravi Stojkovi [Serbie] ; Alessia Verduri [Italie] ; Bianca Beghé [Italie] ; Bin Cao [République populaire de Chine] ; Yahya Shehabi [Australie] ; Jens-Ulrik S. Jensen [Danemark] ; Caspar Corti [Danemark] ; Jos A H. Van Oers [Pays-Bas] ; Albertus Beishuizen [Pays-Bas] ; Armand R J. Girbes [Pays-Bas] ; Evelien De Jong [Pays-Bas] ; Matthias Briel [Canada] ; Beat Mueller [Suisse]Source :
- The Lancet. Infectious diseases [ 1474-4457 ] ; 2017.
Abstract
In February, 2017, the US Food and Drug Administration approved the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute respiratory infections. This meta-analysis of patient data from 26 randomised controlled trials was designed to assess safety of procalcitonin-guided treatment in patients with acute respiratory infections from different clinical settings.
DOI: 10.1016/S1473-3099(17)30592-3
PubMed: 29037960
Affiliations:
- Allemagne, Australie, Belgique, Brésil, Canada, Danemark, France, Italie, Pays-Bas, République populaire de Chine, Serbie, Suisse, États-Unis
- Basse-Saxe, Groningue (province), Hollande-Septentrionale, Hovedstaden, Minas Gerais, Utrecht (province), État de New York, État de São Paulo, Île-de-France
- Amsterdam, Belo Horizonte, Copenhague, Groningue, Hanovre, Paris, Pékin, São Paulo, Utrecht
- Université Pierre-et-Marie-Curie, Université fédérale du Minas Gerais
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Electronic address: schuetzph@gmail.com.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland; Faculty of Medicine, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Wirz, Yannick" sort="Wirz, Yannick" uniqKey="Wirz Y" first="Yannick" last="Wirz">Yannick Wirz</name><affiliation wicri:level="1"><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Medical University Department, Kantonsspital Aarau, Aarau</wicri:regionArea><wicri:noRegion>Aarau</wicri:noRegion></affiliation></author><author><name sortKey="Sager, Ramon" sort="Sager, Ramon" uniqKey="Sager R" first="Ramon" last="Sager">Ramon Sager</name><affiliation wicri:level="1"><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Medical University Department, Kantonsspital Aarau, Aarau</wicri:regionArea><wicri:noRegion>Aarau</wicri:noRegion></affiliation></author><author><name sortKey="Christ Crain, Mirjam" sort="Christ Crain, Mirjam" uniqKey="Christ Crain M" first="Mirjam" last="Christ-Crain">Mirjam Christ-Crain</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Division of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Medicine, University of Basel, Basel, Switzerland; Division of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Stolz, Daiana" sort="Stolz, Daiana" uniqKey="Stolz D" first="Daiana" last="Stolz">Daiana Stolz</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Medicine, University of Basel, Basel, Switzerland; Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Tamm, Michael" sort="Tamm, Michael" uniqKey="Tamm M" first="Michael" last="Tamm">Michael Tamm</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Medicine, University of Basel, Basel, Switzerland; Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Bouadma, Lila" sort="Bouadma, Lila" uniqKey="Bouadma L" first="Lila" last="Bouadma">Lila Bouadma</name><affiliation wicri:level="3"><nlm:affiliation>Service de Réanimation Médicale, Université Paris 7-Denis-Diderot, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation Médicale, Université Paris 7-Denis-Diderot, Assistance Publique Hôpitaux de Paris (AP-HP), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Luyt, Charles E" sort="Luyt, Charles E" uniqKey="Luyt C" first="Charles E" last="Luyt">Charles E. 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Kristoffersen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Infectious Diseases, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Burkhardt, Olaf" sort="Burkhardt, Olaf" uniqKey="Burkhardt O" first="Olaf" last="Burkhardt">Olaf Burkhardt</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pulmonary Medicine, Medizinische Hochschule Hannover, Member of the German Center of Lung Research, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pulmonary Medicine, Medizinische Hochschule Hannover, Member of the German Center of Lung Research, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Welte, Tobias" sort="Welte, Tobias" uniqKey="Welte T" first="Tobias" last="Welte">Tobias Welte</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pulmonary Medicine, Medizinische Hochschule Hannover, Member of the German Center of Lung Research, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pulmonary Medicine, Medizinische Hochschule Hannover, Member of the German Center of Lung Research, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Schroeder, Stefan" sort="Schroeder, Stefan" uniqKey="Schroeder S" first="Stefan" last="Schroeder">Stefan Schroeder</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, Krankenhaus Dueren, Dueren, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, Krankenhaus Dueren, Dueren</wicri:regionArea><wicri:noRegion>Dueren</wicri:noRegion><wicri:noRegion>Dueren</wicri:noRegion><wicri:noRegion>Dueren</wicri:noRegion></affiliation></author><author><name sortKey="Nobre, Vandack" sort="Nobre, Vandack" uniqKey="Nobre V" first="Vandack" last="Nobre">Vandack Nobre</name><affiliation wicri:level="4"><nlm:affiliation>Department of Intensive Care, Hospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Intensive Care, Hospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte</wicri:regionArea><placeName><settlement type="city">Belo Horizonte</settlement><region type="state">Minas Gerais</region><settlement type="city">Belo Horizonte</settlement></placeName><orgName type="university">Université fédérale du Minas Gerais</orgName></affiliation></author><author><name sortKey="Wei, Long" sort="Wei, Long" uniqKey="Wei L" first="Long" last="Wei">Long Wei</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal and Geriatric Medicine, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Internal and Geriatric Medicine, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Bucher, Heiner C" sort="Bucher, Heiner C" uniqKey="Bucher H" first="Heiner C" last="Bucher">Heiner C. Bucher</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Medicine, University of Basel, Basel, Switzerland; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Annane, Djillali" sort="Annane, Djillali" uniqKey="Annane D" first="Djillali" last="Annane">Djillali Annane</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hôpital Raymond Poincaré, AP-HP, Faculty of Health Science Simone Veil, UVSQ-University Paris Saclay, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Critical Care Department, Hôpital Raymond Poincaré, AP-HP, Faculty of Health Science Simone Veil, UVSQ-University Paris Saclay, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Reinhart, Konrad" sort="Reinhart, Konrad" uniqKey="Reinhart K" first="Konrad" last="Reinhart">Konrad Reinhart</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Falsey, Ann R" sort="Falsey, Ann R" uniqKey="Falsey A" first="Ann R" last="Falsey">Ann R. Falsey</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Rochester, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Rochester, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Branche, Angela" sort="Branche, Angela" uniqKey="Branche A" first="Angela" last="Branche">Angela Branche</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Rochester, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Rochester, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Damas, Pierre" sort="Damas, Pierre" uniqKey="Damas P" first="Pierre" last="Damas">Pierre Damas</name><affiliation wicri:level="1"><nlm:affiliation>Department of General Intensive Care, University Hospital of Liege, Domaine Universitaire de Liège, Liège, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of General Intensive Care, University Hospital of Liege, Domaine Universitaire de Liège, Liège</wicri:regionArea><wicri:noRegion>Liège</wicri:noRegion></affiliation></author><author><name sortKey="Nijsten, Maarten" sort="Nijsten, Maarten" uniqKey="Nijsten M" first="Maarten" last="Nijsten">Maarten Nijsten</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Centre, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Centre, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="De Lange, Dylan W" sort="De Lange, Dylan W" uniqKey="De Lange D" first="Dylan W" last="De Lange">Dylan W. De Lange</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center Utrecht and University of Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Utrecht and University of Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Deliberato, Rodrigo O" sort="Deliberato, Rodrigo O" uniqKey="Deliberato R" first="Rodrigo O" last="Deliberato">Rodrigo O. Deliberato</name><affiliation wicri:level="3"><nlm:affiliation>Critical Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Critical Care Unit, Hospital Israelita Albert Einstein, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Oliveira, Carolina F" sort="Oliveira, Carolina F" uniqKey="Oliveira C" first="Carolina F" last="Oliveira">Carolina F. Oliveira</name><affiliation wicri:level="4"><nlm:affiliation>Department of Internal Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Internal Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte</wicri:regionArea><placeName><settlement type="city">Belo Horizonte</settlement><region type="state">Minas Gerais</region><settlement type="city">Belo Horizonte</settlement></placeName><orgName type="university">Université fédérale du Minas Gerais</orgName></affiliation></author><author><name sortKey="Maravi Stojkovi, Vera" sort="Maravi Stojkovi, Vera" uniqKey="Maravi Stojkovi V" first="Vera" last="Maravi Stojkovi">Vera Maravi Stojkovi</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Laboratory, Dedinje Cardiovascular Institute, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Immunology Laboratory, Dedinje Cardiovascular Institute, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Verduri, Alessia" sort="Verduri, Alessia" uniqKey="Verduri A" first="Alessia" last="Verduri">Alessia Verduri</name><affiliation wicri:level="1"><nlm:affiliation>Section of Respiratory Medicine, Department of Medical and Surgical Sciences, University Polyclinic of Modena, University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Respiratory Medicine, Department of Medical and Surgical Sciences, University Polyclinic of Modena, University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Beghe, Bianca" sort="Beghe, Bianca" uniqKey="Beghe B" first="Bianca" last="Beghé">Bianca Beghé</name><affiliation wicri:level="1"><nlm:affiliation>Section of Respiratory Medicine, Department of Medical and Surgical Sciences, University Polyclinic of Modena, University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Respiratory Medicine, Department of Medical and Surgical Sciences, University Polyclinic of Modena, University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Bin" sort="Cao, Bin" uniqKey="Cao B" first="Bin" last="Cao">Bin Cao</name><affiliation wicri:level="3"><nlm:affiliation>Center for Respiratory Diseases, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Respiratory Diseases, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Shehabi, Yahya" sort="Shehabi, Yahya" uniqKey="Shehabi Y" first="Yahya" last="Shehabi">Yahya Shehabi</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care and Peri-operative Medicine, Monash Health, Melbourne, VIC, Australia; School of Clinical Sciences, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Critical Care and Peri-operative Medicine, Monash Health, Melbourne, VIC, Australia; School of Clinical Sciences, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Jensen, Jens Ulrik S" sort="Jensen, Jens Ulrik S" uniqKey="Jensen J" first="Jens-Ulrik S" last="Jensen">Jens-Ulrik S. Jensen</name><affiliation wicri:level="3"><nlm:affiliation>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases and Rheumatology, Finsencentret, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases and Rheumatology, Finsencentret, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Corti, Caspar" sort="Corti, Caspar" uniqKey="Corti C" first="Caspar" last="Corti">Caspar Corti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Respiratory Medicine, Copenhagen University Hospital Bispebjerg, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Van Oers, Jos A H" sort="Van Oers, Jos A H" uniqKey="Van Oers J" first="Jos A H" last="Van Oers">Jos A H. Van Oers</name><affiliation wicri:level="1"><nlm:affiliation>Elisabeth Tweesteden Hospital, Tilburg, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Elisabeth Tweesteden Hospital, Tilburg</wicri:regionArea><wicri:noRegion>Tilburg</wicri:noRegion></affiliation></author><author><name sortKey="Beishuizen, Albertus" sort="Beishuizen, Albertus" uniqKey="Beishuizen A" first="Albertus" last="Beishuizen">Albertus Beishuizen</name><affiliation wicri:level="1"><nlm:affiliation>Medisch Spectrum Twente, Enschede, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Medisch Spectrum Twente, Enschede</wicri:regionArea><wicri:noRegion>Enschede</wicri:noRegion></affiliation></author><author><name sortKey="Girbes, Armand R J" sort="Girbes, Armand R J" uniqKey="Girbes A" first="Armand R J" last="Girbes">Armand R J. Girbes</name><affiliation wicri:level="3"><nlm:affiliation>VUmc University Medical Center, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VUmc University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="De Jong, Evelien" sort="De Jong, Evelien" uniqKey="De Jong E" first="Evelien" last="De Jong">Evelien De Jong</name><affiliation wicri:level="3"><nlm:affiliation>VUmc University Medical Center, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VUmc University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Briel, Matthias" sort="Briel, Matthias" uniqKey="Briel M" first="Matthias" last="Briel">Matthias Briel</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Medicine, University of Basel, Basel, Switzerland; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Mueller, Beat" sort="Mueller, Beat" uniqKey="Mueller B" first="Beat" last="Mueller">Beat Mueller</name><affiliation wicri:level="1"><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland; Faculty of Medicine, University of Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland; Faculty of Medicine, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29037960</idno><idno type="pmid">29037960</idno><idno type="doi">10.1016/S1473-3099(17)30592-3</idno><idno type="wicri:Area/PubMed/Corpus">000374</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000374</idno><idno type="wicri:Area/PubMed/Curation">000372</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000372</idno><idno type="wicri:Area/PubMed/Checkpoint">000372</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000372</idno><idno type="wicri:Area/Ncbi/Merge">005045</idno><idno type="wicri:Area/Ncbi/Curation">005045</idno><idno type="wicri:Area/Ncbi/Checkpoint">005045</idno><idno type="wicri:Area/Main/Merge">000D49</idno><idno type="wicri:Area/Main/Curation">000D54</idno><idno type="wicri:Area/Main/Exploration">000D54</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis.</title><author><name sortKey="Schuetz, Philipp" sort="Schuetz, Philipp" uniqKey="Schuetz P" first="Philipp" last="Schuetz">Philipp Schuetz</name><affiliation wicri:level="1"><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland; Faculty of Medicine, University of Basel, Basel, Switzerland. Electronic address: schuetzph@gmail.com.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland; Faculty of Medicine, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Wirz, Yannick" sort="Wirz, Yannick" uniqKey="Wirz Y" first="Yannick" last="Wirz">Yannick Wirz</name><affiliation wicri:level="1"><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Medical University Department, Kantonsspital Aarau, Aarau</wicri:regionArea><wicri:noRegion>Aarau</wicri:noRegion></affiliation></author><author><name sortKey="Sager, Ramon" sort="Sager, Ramon" uniqKey="Sager R" first="Ramon" last="Sager">Ramon Sager</name><affiliation wicri:level="1"><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Medical University Department, Kantonsspital Aarau, Aarau</wicri:regionArea><wicri:noRegion>Aarau</wicri:noRegion></affiliation></author><author><name sortKey="Christ Crain, Mirjam" sort="Christ Crain, Mirjam" uniqKey="Christ Crain M" first="Mirjam" last="Christ-Crain">Mirjam Christ-Crain</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Division of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Medicine, University of Basel, Basel, Switzerland; Division of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Stolz, Daiana" sort="Stolz, Daiana" uniqKey="Stolz D" first="Daiana" last="Stolz">Daiana Stolz</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Medicine, University of Basel, Basel, Switzerland; Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Tamm, Michael" sort="Tamm, Michael" uniqKey="Tamm M" first="Michael" last="Tamm">Michael Tamm</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Medicine, University of Basel, Basel, Switzerland; Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Bouadma, Lila" sort="Bouadma, Lila" uniqKey="Bouadma L" first="Lila" last="Bouadma">Lila Bouadma</name><affiliation wicri:level="3"><nlm:affiliation>Service de Réanimation Médicale, Université Paris 7-Denis-Diderot, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation Médicale, Université Paris 7-Denis-Diderot, Assistance Publique Hôpitaux de Paris (AP-HP), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Luyt, Charles E" sort="Luyt, Charles E" uniqKey="Luyt C" first="Charles E" last="Luyt">Charles E. Luyt</name><affiliation wicri:level="3"><nlm:affiliation>Service de Réanimation Médicale, Université Paris 6-Pierre-et-Marie-Curie, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation Médicale, Université Paris 6-Pierre-et-Marie-Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Wolff, Michel" sort="Wolff, Michel" uniqKey="Wolff M" first="Michel" last="Wolff">Michel Wolff</name><affiliation wicri:level="3"><nlm:affiliation>Service de Réanimation Médicale, Université Paris 7-Denis-Diderot, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation Médicale, Université Paris 7-Denis-Diderot, Assistance Publique Hôpitaux de Paris (AP-HP), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chastre, Jean" sort="Chastre, Jean" uniqKey="Chastre J" first="Jean" last="Chastre">Jean Chastre</name><affiliation wicri:level="3"><nlm:affiliation>Service de Réanimation Médicale, Université Paris 6-Pierre-et-Marie-Curie, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation Médicale, Université Paris 6-Pierre-et-Marie-Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tubach, Florence" sort="Tubach, Florence" uniqKey="Tubach F" first="Florence" last="Tubach">Florence Tubach</name><affiliation wicri:level="4"><nlm:affiliation>Département de Biostatistique, Santé publique et Information médicale, AP-HP, Hôpital Pitié-Salpêtrière, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Biostatistique, Santé publique et Information médicale, AP-HP, Hôpital Pitié-Salpêtrière, Université Pierre et Marie Curie, Sorbonne Universités, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Kristoffersen, Kristina B" sort="Kristoffersen, Kristina B" uniqKey="Kristoffersen K" first="Kristina B" last="Kristoffersen">Kristina B. Kristoffersen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Infectious Diseases, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Burkhardt, Olaf" sort="Burkhardt, Olaf" uniqKey="Burkhardt O" first="Olaf" last="Burkhardt">Olaf Burkhardt</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pulmonary Medicine, Medizinische Hochschule Hannover, Member of the German Center of Lung Research, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pulmonary Medicine, Medizinische Hochschule Hannover, Member of the German Center of Lung Research, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Welte, Tobias" sort="Welte, Tobias" uniqKey="Welte T" first="Tobias" last="Welte">Tobias Welte</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pulmonary Medicine, Medizinische Hochschule Hannover, Member of the German Center of Lung Research, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pulmonary Medicine, Medizinische Hochschule Hannover, Member of the German Center of Lung Research, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Schroeder, Stefan" sort="Schroeder, Stefan" uniqKey="Schroeder S" first="Stefan" last="Schroeder">Stefan Schroeder</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, Krankenhaus Dueren, Dueren, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, Krankenhaus Dueren, Dueren</wicri:regionArea><wicri:noRegion>Dueren</wicri:noRegion><wicri:noRegion>Dueren</wicri:noRegion><wicri:noRegion>Dueren</wicri:noRegion></affiliation></author><author><name sortKey="Nobre, Vandack" sort="Nobre, Vandack" uniqKey="Nobre V" first="Vandack" last="Nobre">Vandack Nobre</name><affiliation wicri:level="4"><nlm:affiliation>Department of Intensive Care, Hospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Intensive Care, Hospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte</wicri:regionArea><placeName><settlement type="city">Belo Horizonte</settlement><region type="state">Minas Gerais</region><settlement type="city">Belo Horizonte</settlement></placeName><orgName type="university">Université fédérale du Minas Gerais</orgName></affiliation></author><author><name sortKey="Wei, Long" sort="Wei, Long" uniqKey="Wei L" first="Long" last="Wei">Long Wei</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal and Geriatric Medicine, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Internal and Geriatric Medicine, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Bucher, Heiner C" sort="Bucher, Heiner C" uniqKey="Bucher H" first="Heiner C" last="Bucher">Heiner C. Bucher</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Medicine, University of Basel, Basel, Switzerland; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Annane, Djillali" sort="Annane, Djillali" uniqKey="Annane D" first="Djillali" last="Annane">Djillali Annane</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Hôpital Raymond Poincaré, AP-HP, Faculty of Health Science Simone Veil, UVSQ-University Paris Saclay, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Critical Care Department, Hôpital Raymond Poincaré, AP-HP, Faculty of Health Science Simone Veil, UVSQ-University Paris Saclay, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Reinhart, Konrad" sort="Reinhart, Konrad" uniqKey="Reinhart K" first="Konrad" last="Reinhart">Konrad Reinhart</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Falsey, Ann R" sort="Falsey, Ann R" uniqKey="Falsey A" first="Ann R" last="Falsey">Ann R. Falsey</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Rochester, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Rochester, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Branche, Angela" sort="Branche, Angela" uniqKey="Branche A" first="Angela" last="Branche">Angela Branche</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Rochester, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Rochester, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Damas, Pierre" sort="Damas, Pierre" uniqKey="Damas P" first="Pierre" last="Damas">Pierre Damas</name><affiliation wicri:level="1"><nlm:affiliation>Department of General Intensive Care, University Hospital of Liege, Domaine Universitaire de Liège, Liège, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of General Intensive Care, University Hospital of Liege, Domaine Universitaire de Liège, Liège</wicri:regionArea><wicri:noRegion>Liège</wicri:noRegion></affiliation></author><author><name sortKey="Nijsten, Maarten" sort="Nijsten, Maarten" uniqKey="Nijsten M" first="Maarten" last="Nijsten">Maarten Nijsten</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Centre, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Centre, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="De Lange, Dylan W" sort="De Lange, Dylan W" uniqKey="De Lange D" first="Dylan W" last="De Lange">Dylan W. De Lange</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center Utrecht and University of Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Utrecht and University of Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Deliberato, Rodrigo O" sort="Deliberato, Rodrigo O" uniqKey="Deliberato R" first="Rodrigo O" last="Deliberato">Rodrigo O. Deliberato</name><affiliation wicri:level="3"><nlm:affiliation>Critical Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Critical Care Unit, Hospital Israelita Albert Einstein, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Oliveira, Carolina F" sort="Oliveira, Carolina F" uniqKey="Oliveira C" first="Carolina F" last="Oliveira">Carolina F. Oliveira</name><affiliation wicri:level="4"><nlm:affiliation>Department of Internal Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Internal Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte</wicri:regionArea><placeName><settlement type="city">Belo Horizonte</settlement><region type="state">Minas Gerais</region><settlement type="city">Belo Horizonte</settlement></placeName><orgName type="university">Université fédérale du Minas Gerais</orgName></affiliation></author><author><name sortKey="Maravi Stojkovi, Vera" sort="Maravi Stojkovi, Vera" uniqKey="Maravi Stojkovi V" first="Vera" last="Maravi Stojkovi">Vera Maravi Stojkovi</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Laboratory, Dedinje Cardiovascular Institute, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Immunology Laboratory, Dedinje Cardiovascular Institute, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Verduri, Alessia" sort="Verduri, Alessia" uniqKey="Verduri A" first="Alessia" last="Verduri">Alessia Verduri</name><affiliation wicri:level="1"><nlm:affiliation>Section of Respiratory Medicine, Department of Medical and Surgical Sciences, University Polyclinic of Modena, University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Respiratory Medicine, Department of Medical and Surgical Sciences, University Polyclinic of Modena, University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Beghe, Bianca" sort="Beghe, Bianca" uniqKey="Beghe B" first="Bianca" last="Beghé">Bianca Beghé</name><affiliation wicri:level="1"><nlm:affiliation>Section of Respiratory Medicine, Department of Medical and Surgical Sciences, University Polyclinic of Modena, University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Respiratory Medicine, Department of Medical and Surgical Sciences, University Polyclinic of Modena, University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Bin" sort="Cao, Bin" uniqKey="Cao B" first="Bin" last="Cao">Bin Cao</name><affiliation wicri:level="3"><nlm:affiliation>Center for Respiratory Diseases, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Respiratory Diseases, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Shehabi, Yahya" sort="Shehabi, Yahya" uniqKey="Shehabi Y" first="Yahya" last="Shehabi">Yahya Shehabi</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care and Peri-operative Medicine, Monash Health, Melbourne, VIC, Australia; School of Clinical Sciences, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Critical Care and Peri-operative Medicine, Monash Health, Melbourne, VIC, Australia; School of Clinical Sciences, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Jensen, Jens Ulrik S" sort="Jensen, Jens Ulrik S" uniqKey="Jensen J" first="Jens-Ulrik S" last="Jensen">Jens-Ulrik S. Jensen</name><affiliation wicri:level="3"><nlm:affiliation>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases and Rheumatology, Finsencentret, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases and Rheumatology, Finsencentret, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Corti, Caspar" sort="Corti, Caspar" uniqKey="Corti C" first="Caspar" last="Corti">Caspar Corti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Respiratory Medicine, Copenhagen University Hospital Bispebjerg, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Van Oers, Jos A H" sort="Van Oers, Jos A H" uniqKey="Van Oers J" first="Jos A H" last="Van Oers">Jos A H. Van Oers</name><affiliation wicri:level="1"><nlm:affiliation>Elisabeth Tweesteden Hospital, Tilburg, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Elisabeth Tweesteden Hospital, Tilburg</wicri:regionArea><wicri:noRegion>Tilburg</wicri:noRegion></affiliation></author><author><name sortKey="Beishuizen, Albertus" sort="Beishuizen, Albertus" uniqKey="Beishuizen A" first="Albertus" last="Beishuizen">Albertus Beishuizen</name><affiliation wicri:level="1"><nlm:affiliation>Medisch Spectrum Twente, Enschede, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Medisch Spectrum Twente, Enschede</wicri:regionArea><wicri:noRegion>Enschede</wicri:noRegion></affiliation></author><author><name sortKey="Girbes, Armand R J" sort="Girbes, Armand R J" uniqKey="Girbes A" first="Armand R J" last="Girbes">Armand R J. Girbes</name><affiliation wicri:level="3"><nlm:affiliation>VUmc University Medical Center, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VUmc University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="De Jong, Evelien" sort="De Jong, Evelien" uniqKey="De Jong E" first="Evelien" last="De Jong">Evelien De Jong</name><affiliation wicri:level="3"><nlm:affiliation>VUmc University Medical Center, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VUmc University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Briel, Matthias" sort="Briel, Matthias" uniqKey="Briel M" first="Matthias" last="Briel">Matthias Briel</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Medicine, University of Basel, Basel, Switzerland; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Mueller, Beat" sort="Mueller, Beat" uniqKey="Mueller B" first="Beat" last="Mueller">Beat Mueller</name><affiliation wicri:level="1"><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland; Faculty of Medicine, University of Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland; Faculty of Medicine, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Lancet. Infectious diseases</title><idno type="eISSN">1474-4457</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In February, 2017, the US Food and Drug Administration approved the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute respiratory infections. This meta-analysis of patient data from 26 randomised controlled trials was designed to assess safety of procalcitonin-guided treatment in patients with acute respiratory infections from different clinical settings.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Brésil</li><li>Canada</li><li>Danemark</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>République populaire de Chine</li><li>Serbie</li><li>Suisse</li><li>États-Unis</li></country><region><li>Basse-Saxe</li><li>Groningue (province)</li><li>Hollande-Septentrionale</li><li>Hovedstaden</li><li>Minas Gerais</li><li>Utrecht (province)</li><li>État de New York</li><li>État de São Paulo</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Belo Horizonte</li><li>Copenhague</li><li>Groningue</li><li>Hanovre</li><li>Paris</li><li>Pékin</li><li>São Paulo</li><li>Utrecht</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li><li>Université fédérale du Minas Gerais</li></orgName></list><tree><country name="Suisse"><noRegion><name sortKey="Schuetz, Philipp" sort="Schuetz, Philipp" uniqKey="Schuetz P" first="Philipp" last="Schuetz">Philipp Schuetz</name></noRegion><name sortKey="Bucher, Heiner C" sort="Bucher, Heiner C" uniqKey="Bucher H" first="Heiner C" last="Bucher">Heiner C. Bucher</name><name sortKey="Christ Crain, Mirjam" sort="Christ Crain, Mirjam" uniqKey="Christ Crain M" first="Mirjam" last="Christ-Crain">Mirjam Christ-Crain</name><name sortKey="Mueller, Beat" sort="Mueller, Beat" uniqKey="Mueller B" first="Beat" last="Mueller">Beat Mueller</name><name sortKey="Sager, Ramon" sort="Sager, Ramon" uniqKey="Sager R" first="Ramon" last="Sager">Ramon Sager</name><name sortKey="Stolz, Daiana" sort="Stolz, Daiana" uniqKey="Stolz D" first="Daiana" last="Stolz">Daiana Stolz</name><name sortKey="Tamm, Michael" sort="Tamm, Michael" uniqKey="Tamm M" first="Michael" last="Tamm">Michael Tamm</name><name sortKey="Wirz, Yannick" sort="Wirz, Yannick" uniqKey="Wirz Y" first="Yannick" last="Wirz">Yannick Wirz</name></country><country name="France"><region name="Île-de-France"><name sortKey="Bouadma, Lila" sort="Bouadma, Lila" uniqKey="Bouadma L" first="Lila" last="Bouadma">Lila Bouadma</name></region><name sortKey="Annane, Djillali" sort="Annane, Djillali" uniqKey="Annane D" first="Djillali" last="Annane">Djillali Annane</name><name sortKey="Chastre, Jean" sort="Chastre, Jean" uniqKey="Chastre J" first="Jean" last="Chastre">Jean Chastre</name><name sortKey="Luyt, Charles E" sort="Luyt, Charles E" uniqKey="Luyt C" first="Charles E" last="Luyt">Charles E. Luyt</name><name sortKey="Tubach, Florence" sort="Tubach, Florence" uniqKey="Tubach F" first="Florence" last="Tubach">Florence Tubach</name><name sortKey="Wolff, Michel" sort="Wolff, Michel" uniqKey="Wolff M" first="Michel" last="Wolff">Michel Wolff</name></country><country name="Danemark"><noRegion><name sortKey="Kristoffersen, Kristina B" sort="Kristoffersen, Kristina B" uniqKey="Kristoffersen K" first="Kristina B" last="Kristoffersen">Kristina B. Kristoffersen</name></noRegion><name sortKey="Corti, Caspar" sort="Corti, Caspar" uniqKey="Corti C" first="Caspar" last="Corti">Caspar Corti</name><name sortKey="Jensen, Jens Ulrik S" sort="Jensen, Jens Ulrik S" uniqKey="Jensen J" first="Jens-Ulrik S" last="Jensen">Jens-Ulrik S. Jensen</name></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Burkhardt, Olaf" sort="Burkhardt, Olaf" uniqKey="Burkhardt O" first="Olaf" last="Burkhardt">Olaf Burkhardt</name></region><name sortKey="Reinhart, Konrad" sort="Reinhart, Konrad" uniqKey="Reinhart K" first="Konrad" last="Reinhart">Konrad Reinhart</name><name sortKey="Schroeder, Stefan" sort="Schroeder, Stefan" uniqKey="Schroeder S" first="Stefan" last="Schroeder">Stefan Schroeder</name><name sortKey="Welte, Tobias" sort="Welte, Tobias" uniqKey="Welte T" first="Tobias" last="Welte">Tobias Welte</name></country><country name="Brésil"><region name="Minas Gerais"><name sortKey="Nobre, Vandack" sort="Nobre, Vandack" uniqKey="Nobre V" first="Vandack" last="Nobre">Vandack Nobre</name></region><name sortKey="Deliberato, Rodrigo O" sort="Deliberato, Rodrigo O" uniqKey="Deliberato R" first="Rodrigo O" last="Deliberato">Rodrigo O. Deliberato</name><name sortKey="Oliveira, Carolina F" sort="Oliveira, Carolina F" uniqKey="Oliveira C" first="Carolina F" last="Oliveira">Carolina F. Oliveira</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Wei, Long" sort="Wei, Long" uniqKey="Wei L" first="Long" last="Wei">Long Wei</name></noRegion><name sortKey="Cao, Bin" sort="Cao, Bin" uniqKey="Cao B" first="Bin" last="Cao">Bin Cao</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Falsey, Ann R" sort="Falsey, Ann R" uniqKey="Falsey A" first="Ann R" last="Falsey">Ann R. Falsey</name></region><name sortKey="Branche, Angela" sort="Branche, Angela" uniqKey="Branche A" first="Angela" last="Branche">Angela Branche</name></country><country name="Belgique"><noRegion><name sortKey="Damas, Pierre" sort="Damas, Pierre" uniqKey="Damas P" first="Pierre" last="Damas">Pierre Damas</name></noRegion></country><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Nijsten, Maarten" sort="Nijsten, Maarten" uniqKey="Nijsten M" first="Maarten" last="Nijsten">Maarten Nijsten</name></region><name sortKey="Beishuizen, Albertus" sort="Beishuizen, Albertus" uniqKey="Beishuizen A" first="Albertus" last="Beishuizen">Albertus Beishuizen</name><name sortKey="De Jong, Evelien" sort="De Jong, Evelien" uniqKey="De Jong E" first="Evelien" last="De Jong">Evelien De Jong</name><name sortKey="De Lange, Dylan W" sort="De Lange, Dylan W" uniqKey="De Lange D" first="Dylan W" last="De Lange">Dylan W. De Lange</name><name sortKey="Girbes, Armand R J" sort="Girbes, Armand R J" uniqKey="Girbes A" first="Armand R J" last="Girbes">Armand R J. Girbes</name><name sortKey="Van Oers, Jos A H" sort="Van Oers, Jos A H" uniqKey="Van Oers J" first="Jos A H" last="Van Oers">Jos A H. Van Oers</name></country><country name="Serbie"><noRegion><name sortKey="Maravi Stojkovi, Vera" sort="Maravi Stojkovi, Vera" uniqKey="Maravi Stojkovi V" first="Vera" last="Maravi Stojkovi">Vera Maravi Stojkovi</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Verduri, Alessia" sort="Verduri, Alessia" uniqKey="Verduri A" first="Alessia" last="Verduri">Alessia Verduri</name></noRegion><name sortKey="Beghe, Bianca" sort="Beghe, Bianca" uniqKey="Beghe B" first="Bianca" last="Beghé">Bianca Beghé</name></country><country name="Australie"><noRegion><name sortKey="Shehabi, Yahya" sort="Shehabi, Yahya" uniqKey="Shehabi Y" first="Yahya" last="Shehabi">Yahya Shehabi</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Briel, Matthias" sort="Briel, Matthias" uniqKey="Briel M" first="Matthias" last="Briel">Matthias Briel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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